Recombinant Human Neutrophil defensin 3 (DEFA3)

Uniprot Id

P59666

Target Species

Human

Target Name

DEFA3

Target Full Name

Neutrophil defensin 3

Target Function

Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

Target Subcellular Location

Secreted.

Target Protein Families

Alpha-defensin family

Target Research Area

Others

Target Synonyms

DEFA3; DEF3Neutrophil defensin 3; Defensin; alpha 3; HNP-3; HP-3; HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2; HNP-2; HP-2; HP2)]

Target Background

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.