Recombinant Human Noelin-2 (OLFM2)

Uniprot Id

O95897

Target Species

Human

Target Name

OLFM2

Target Full Name

Noelin-2

Target Function

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling.

Target Subcellular Location

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm.

Target Tissue Specificity

Expressed in aortic smooth muscle (at protein level). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup.

Target Synonyms

Neuronal olfactomedin related ER localized protein 2; NOE2; NOE2_HUMAN; Noelin 2; Noelin-2; NOELIN2; NOELIN2 V1; Olfactomedin 2; Olfactomedin-2; OlfC; Olfm2