Recombinant Human Nuclear pore complex protein Nup93 (NUP93), Truncated

Uniprot Id

Q8N1F7

Target Species

Human

Target Name

NUP93

Target Full Name

Nuclear pore complex protein Nup93

Target Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.

Target Involvement

Nephrotic syndrome 12 (NPHS12)

Target Subcellular Location

Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Nucleus envelope.

Target Protein Families

Nucleoporin interacting component (NIC) family

Target Synonyms

NUP93; KIAA0095Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93

Target Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms.