Recombinant Human Nuclear transport factor 2 (NUTF2)

Uniprot Id

P61970

Target Species

Human

Target Name

NUTF2

Target Full Name

Nuclear transport factor 2

Target Function

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Target Subcellular Location

Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm.

Target Research Area

Signal Transduction

Target Synonyms

NTF 2; NTF-2; NTF2; NTF2_HUMAN; Nuclear transport factor 2; Nutf2; Placental protein 15; PP15

Target Background

This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62.