Recombinant Human Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS1)

Uniprot Id

Q9H1E3

Target Species

Human

Target Name

NUCKS1

Target Full Name

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Target Function

Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.

Target Subcellular Location

Nucleus. Chromosome.

Target Tissue Specificity

Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.

Target Synonyms

FLJ21480; FLJ32016; FLJ38536; JC7; NUCKS 1; NUCKS; NUCKS_HUMAN; Nucks1; Nuclear casein kinase and cyclin dependent kinase substrate 1; Nuclear ubiquitous casein and cyclin dependent kinases substrate; Nuclear ubiquitous casein and cyclin-dependent kinases substrate; Nuclear ubiquitous casein kinase and cyclin dependent kinase substrate; P1; Potential LAG1 interactor

Target Background

This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle.