Recombinant Human Nucleoside diphosphate kinase 7 (NME7)

Uniprot Id

Q9Y5B8

Target Species

Human

Target Name

NME7

Target Full Name

Nucleoside diphosphate kinase homolog 7

Target Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Target Protein Families

NDK family

Target Synonyms

MN23H7; NDK 7; NDK7_HUMAN; NDP kinase 7; nm23 H7 ; nm23-H7; NME/NM23 family member 7; Nme7; Non metastatic cells 7 protein expressed in (nucleoside diphosphate kinase); Nucleoside diphosphate kinase 7

Target Background

This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants.