Recombinant Human Obg-like ATPase 1 (OLA1)

Uniprot Id

Q9NTK5

Target Species

Human

Target Name

OLA1

Target Full Name

Obg-like ATPase 1

Target Function

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

Target Subcellular Location

Cytoplasm. Nucleus. Nucleus, nucleolus.

Target Protein Families

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily

Target Tissue Specificity

Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.

Target Research Area

Signal Transduction

Target Synonyms

DKFZp313H1942; DNA damage-regulated overexpressed in cancer 45 protein; DOC45; EC 3.6.3; GBP45; GTP-binding protein 9 (putative); GTP-binding protein 9; GTP-binding protein PTD004; homologous yeast-44.2 protein; Obg like ATPase 1; Obg-like ATPase 1; OLA1; OLA1_HUMAN; PTD004

Target Background

This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22.