Recombinant Human Oxysterol-binding protein-related protein 10 (OSBPL10)

Uniprot Id

Q9BXB5

Target Species

Human

Target Name

OSBPL10

Target Full Name

Oxysterol-binding protein-related protein 10

Target Function

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

OSBP family

Target Synonyms

FLJ20363 ; ORP-10; ORP10 ; OSB10_HUMAN; OSBP related protein 10; OSBP-related protein 10; OSBP9 ; OSBPL 10; OSBPL10; Oxysterol binding protein like 10; Oxysterol binding protein related protein 10; Oxysterol-binding protein-related protein 10

Target Background

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene.