Recombinant Human p21-activated protein kinase-interacting protein 1 (PAK1IP1)

Uniprot Id

Q9NWT1

Target Species

Human

Target Name

PAK1IP1

Target Full Name

p21-activated protein kinase-interacting protein 1

Target Function

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.

Target Subcellular Location

Nucleus, nucleolus.

Target Tissue Specificity

Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.

Target Synonyms

PAK1IP1; PIP1; WDR84; p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1; PAK1-interacting protein 1; WD repeat-containing protein 84

Target Background

Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus.