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| Cat.No | ACP11716 | Target Name | PARPBP |
|---|---|---|---|
| Target Synonyms | AROM; C12orf48; Chromosome 12 open reading frame 48; FLJ20641; PARP 1 binding protein; PARP-1 binding protein; PARP1 binding protein; PARP1-binding protein; PARPBP; PR1BP_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-579 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NWS1 |
|---|
Uniprot Id
Q9NWS1
Target Species
Human
Target Name
PARPBP
Target Full Name
PCNA-interacting partner
Target Function
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.
Target Protein Families
PARI family
Target Tissue Specificity
Restricted to testis. Overexpressed in multiple cancer cells.
Target Synonyms
AROM; C12orf48; Chromosome 12 open reading frame 48; FLJ20641; PARP 1 binding protein; PARP-1 binding protein; PARP1 binding protein; PARP1-binding protein; PARPBP; PR1BP_HUMAN
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