Recombinant Human PH-interacting protein (PHIP), Truncated

Uniprot Id

Q8WWQ0

Target Species

Human

Target Name

PHIP

Target Full Name

PH-interacting protein

Target Function

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in myeloma and epidermoid carcinoma cell lines.

Target Synonyms

PHIP; DCAF14; WDR11; PH-interacting protein; PHIP; DDB1- and CUL4-associated factor 14; IRS-1 PH domain-binding protein; WD repeat-containing protein 11

Target Background

This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients.