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This Human PLSCR1 recombinant protein was produced in E.coli, where the gene sequence encoding Human PLSCR1 (1-318aa) was expressed with the N-terminal GST tag. The purity of this PLSCR1 protein was greater than 90% by SDS-PAGE.PLSCR1 is a phospholipid scramblase, and its primary function is to facilitate the translocation (flipping) of phospholipids on the cell membrane between the inner and outer layers, a process that is typically regulated under normal circumstances. PLSCR1 can expose phospholipids on the cell surface, participating in various biological processes such as cell apoptosis, blood clotting, and immune responses. PLSCR1 is widely distributed in various tissues and cell types, including immune cells, nerve cells, muscle cells, and more. It plays crucial regulatory roles in different biological processes. For example, the activation of PLSCR1 is closely associated with phospholipid externalization during cell apoptosis, cell clotting, immune responses, and more. PLSCR1 is linked to certain diseases and physiological processes. For instance, it is associated with tumor development and progression, immune system regulation, viral invasion, and more. Aberrant expression of PLSCR1 in certain tumors is related to uncontrolled cell apoptosis and tumor growth. Due to its involvement in various biological processes like cell apoptosis, cancer, and immune regulation, PLSCR1 is of significant interest in medical research. Researchers are exploring the potential applications of PLSCR1 in cancer therapy, immune disease treatment, and the management of inflammatory conditions.
This Human PLSCR1 recombinant protein was produced in E.coli, where the gene sequence encoding Human PLSCR1 (1-318aa) was expressed with the N-terminal GST tag. The purity of this PLSCR1 protein was greater than 90% by SDS-PAGE.PLSCR1 is a phospholipid scramblase, and its primary function is to facilitate the translocation (flipping) of phospholipids on the cell membrane between the inner and outer layers, a process that is typically regulated under normal circumstances. PLSCR1 can expose phospholipids on the cell surface, participating in various biological processes such as cell apoptosis, blood clotting, and immune responses. PLSCR1 is widely distributed in various tissues and cell types, including immune cells, nerve cells, muscle cells, and more. It plays crucial regulatory roles in different biological processes. For example, the activation of PLSCR1 is closely associated with phospholipid externalization during cell apoptosis, cell clotting, immune responses, and more. PLSCR1 is linked to certain diseases and physiological processes. For instance, it is associated with tumor development and progression, immune system regulation, viral invasion, and more. Aberrant expression of PLSCR1 in certain tumors is related to uncontrolled cell apoptosis and tumor growth. Due to its involvement in various biological processes like cell apoptosis, cancer, and immune regulation, PLSCR1 is of significant interest in medical research. Researchers are exploring the potential applications of PLSCR1 in cancer therapy, immune disease treatment, and the management of inflammatory conditions.
| Cat.No | ACP03464 | Target Name | PLSCR1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-318aa | Mol Weight | 61.7 kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15162 |
|---|
Uniprot Id
O15162
Target Species
Human
Target Name
PLSCR1
Target Full Name
Phospholipid scramblase 1
Target Function
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation. May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. Acts as an attachment receptor for HCV.
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
Target Protein Families
Phospholipid scramblase family
Target Tissue Specificity
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
Target Research Area
Microbiology
Target Synonyms
Ca(2+) dependent phospholipid scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MM1 cell-derived transplantability-associated gene 1b; mouse; homolog of; MmTRA1a; MmTRA1b; Nor1; Phospholipid scramblase 1; PL scramblase 1; PLS1_HUMAN; PLSCR 1; Plscr1; Scramblase1; Tra1; Tra1a; Tra1b; Transplantability-associated protein 1; Tras1; Tras2
Target Background
This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses.
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