Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The production of this Recombinant Human PGF protein required the insertion of a DNA fragment (PGF, 19-170aa) into a plasmid vector and the transferral of this vector into E.coli cells (the step of transformation). The cells were then cultured and induced to express the PGF protein. This recombinant protein was fused with N-terminal 6xHis-SUMO tag. Its purity is 90%+ determined by SDS-PAGE.PGF (also named PGFL or PLGF) is a gene providing an instruction of making a protein named placenta growth factor (also known as PGF or PlGF) in human. PGF protein is a member of the VEGF subfamily, which is a key molecule in angiogenesis and vasculogenesis. Although it was first described in the placenta, it has been identified in low levels in other tissues. PGF protein has been implicated in a variety of physiological processes, including animal organ regeneration, cell differentiation, induction of positive chemotaxis, vascular endothelial growth factor receptor signaling pathway, etc.
The production of this Recombinant Human PGF protein required the insertion of a DNA fragment (PGF, 19-170aa) into a plasmid vector and the transferral of this vector into E.coli cells (the step of transformation). The cells were then cultured and induced to express the PGF protein. This recombinant protein was fused with N-terminal 6xHis-SUMO tag. Its purity is 90%+ determined by SDS-PAGE.PGF (also named PGFL or PLGF) is a gene providing an instruction of making a protein named placenta growth factor (also known as PGF or PlGF) in human. PGF protein is a member of the VEGF subfamily, which is a key molecule in angiogenesis and vasculogenesis. Although it was first described in the placenta, it has been identified in low levels in other tissues. PGF protein has been implicated in a variety of physiological processes, including animal organ regeneration, cell differentiation, induction of positive chemotaxis, vascular endothelial growth factor receptor signaling pathway, etc.
| Cat.No | ACP04381 | Target Name | PGF |
|---|---|---|---|
| Target Synonyms | D12S1900; Pgf; PGFL; PIGF; Placenta growth factor; Placental growth factor; Placental growth factor; vascular endothelial growth factor related protein; PlGF 2; PlGF; PLGF_HUMAN; PlGF2; SHGC 10760 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 19-170aa |
| Mol Weight | 33.3kDa | Protein Length | Full Length of Mature Protein of Isoform PlGF-2 |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P49763 |
|---|
Uniprot Id
P49763
Target Species
Human
Target Name
PGF
Target Full Name
Placenta growth factor
Target Function
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Target Subcellular Location
Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Target Protein Families
PDGF/VEGF growth factor family
Target Tissue Specificity
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Target Research Area
Cardiovascular
Target Synonyms
D12S1900; Pgf; PGFL; PIGF; Placenta growth factor; Placental growth factor; Placental growth factor; vascular endothelial growth factor related protein; PlGF 2; PlGF; PLGF_HUMAN; PlGF2; SHGC 10760
Target Background
Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
