Recombinant Human Pleckstrin homology-like domain family A member 3 (PHLDA3)

Uniprot Id

Q9Y5J5

Target Species

Human

Target Name

PHLDA3

Target Full Name

Pleckstrin homology-like domain family A member 3

Target Function

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Target Protein Families

PHLDA3 family

Target Tissue Specificity

Widely expressed with lowest expression in liver and spleen.

Target Synonyms

PHLA3_HUMAN; PHLDA 3; phlda3; Pleckstrin homology like domain family A member 2; Pleckstrin homology like domain family A member 3; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; TDAG51/Ipl homologue 1; TIH 1; TIH1

Target Background

Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3, 4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane.