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| Cat.No | ACP00487 | Target Name | NPHS2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 124-315aa | Mol Weight | 28.2 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NP85 |
|---|
Uniprot Id
Q9NP85
Target Species
Human
Target Name
NPHS2
Target Full Name
Podocin
Target Function
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Target Involvement
Nephrotic syndrome 2 (NPHS2)
Target Subcellular Location
[Isoform 1]: Cell membrane; Peripheral membrane protein.; [Isoform 2]: Endoplasmic reticulum.
Target Protein Families
Band 7/mec-2 family
Target Tissue Specificity
Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.
Target Research Area
Cell Biology
Target Synonyms
nephrosis 2; Nephrosis 2, idiopathic, steroid resistant (podocin); nephrosis 2, idiopathic, steroid resistant; NPHS2; NPHS2 gene; PDCN; PODO_HUMAN; Podocin; SRN1
Target Background
This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants.
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