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| Cat.No | ACP15363 | Target Name | PCGF5 |
|---|---|---|---|
| Target Synonyms | MGC16202; OTTHUMP00000020085; PCGF 5; PCGF5; PCGF5_HUMAN; Polycomb group ring finger 5; Polycomb group RING finger protein 5; Ring finger protein (C3HC4 type) 159; RING finger protein 159; RNF159 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-256 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86SE9 |
|---|
Uniprot Id
Q86SE9
Target Species
Human
Target Name
PCGF5
Target Full Name
Polycomb group RING finger protein 5
Target Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females
Target Subcellular Location
Nucleus. Nucleus, nucleoplasm.
Target Synonyms
MGC16202; OTTHUMP00000020085; PCGF 5; PCGF5; PCGF5_HUMAN; Polycomb group ring finger 5; Polycomb group RING finger protein 5; Ring finger protein (C3HC4 type) 159; RING finger protein 159; RNF159
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