Recombinant Human Polyhomeotic-like protein 1 (PHC1), Truncated

Uniprot Id

P78364

Target Species

Human

Target Name

PHC1

Target Full Name

Polyhomeotic-like protein 1

Target Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.

Target Involvement

Microcephaly 11, primary, autosomal recessive (MCPH11)

Target Subcellular Location

Nucleus.

Target Synonyms

Early development regulatory protein 1; hPH1; mPH1; PH1; Phc1; PHC1_HUMAN; Polyhomeotic-like protein 1; Rae28

Target Background

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.