Recombinant Human Potassium channel subfamily K member 18 (KCNK18), Truncated

Uniprot Id

Q7Z418

Target Species

Human

Target Name

KCNK18

Target Full Name

Potassium channel subfamily K member 18

Target Function

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation

Target Involvement

Migraine with or without aura 13 (MGR13)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Two pore domain potassium channel (TC 1.A.1.8) family

Target Tissue Specificity

Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.

Target Synonyms

KCNK18; TRESK; TRIK; Potassium channel subfamily K member 18; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel