Recombinant Human Potassium channel subfamily K member 9 (KCNK9), Truncated

Uniprot Id

Q9NPC2

Target Species

Human

Target Name

KCNK9

Target Full Name

Potassium channel subfamily K member 9

Target Function

pH-dependent, voltage-insensitive, background potassium channel protein.

Target Involvement

Birk-Barel mental retardation dysmorphism syndrome (BIBAS)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Two pore domain potassium channel (TC 1.A.1.8) family

Target Tissue Specificity

Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.

Target Synonyms

KCNK9; TASK3; Potassium channel subfamily K member 9; Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K(+ channel 3; Two pore potassium channel KT3.2; Two pore K(+ channel KT3.2

Target Background

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants.