Recombinant Human Potassium-transporting ATPase alpha chain 2 (ATP12A), Truncated

Uniprot Id

P54707

Target Species

Human

Target Name

ATP12A

Target Full Name

Potassium-transporting ATPase alpha chain 2

Target Function

The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment. Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon. In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance.

Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily

Target Tissue Specificity

Expressed in airway epithelial cells (at protein level). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).

Target Synonyms

ATP12A; ATP1AL1Potassium-transporting ATPase alpha chain 2; EC 7.2.2.19; Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump

Target Background

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene.