Recombinant Human Potassium voltage-gated channel subfamily E member 4 (KCNE4), Truncated

Uniprot Id

Q8WWG9

Target Species

Human

Target Name

KCNE4

Target Full Name

Potassium voltage-gated channel subfamily E member 4

Target Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

Target Subcellular Location

Membrane; Single-pass membrane protein.

Target Protein Families

Potassium channel KCNE family

Target Tissue Specificity

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.

Target Synonyms

KCNE4; Potassium voltage-gated channel subfamily E member 4; MinK-related peptide 3; Minimum potassium ion channel-related peptide 3; Potassium channel subunit beta MiRP3

Target Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.