Recombinant Human PR domain zinc finger protein 16 (PRDM16), Truncated

Cat.No	ACP11502	Target Name	PRDM16
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP11502

Target Name

PRDM16

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HAZ2

Background Information

Uniprot Id

Q9HAZ2
Target Species

Human
Target Name

PRDM16
Target Full Name

Histone-lysine N-methyltransferase PRDM16
Target Function

Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions as a repressor of TGF-beta signaling.; Binds DNA and functions as a transcriptional regulator. Functions as a repressor of TGF-beta signaling. May regulate granulocyte differentiation.
Target Involvement

Left ventricular non-compaction 8 (LVNC8); Cardiomyopathy, dilated 1LL (CMD1LL)
Target Subcellular Location

Nucleus. Cytoplasm.
Target Tissue Specificity

Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
Target Synonyms

CMD1LL; KIAA1675; LVNC8; MDS1/EVI1 like gene 1; MDS1/EVI1-like gene 1; MEL1; PFM 13; PFM13; PR domain containing 16; PR domain containing protein 16; PR domain zinc finger protein 16; PR domain-containing protein 16; PRD16_HUMAN; Prdm16; Transcription factor MEL 1; Transcription factor MEL1

Recombinant Human PR domain zinc finger protein 16 (PRDM16), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human PR domain zinc finger protein 16 (PRDM16), Truncated Now

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