Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C), Truncated

Uniprot Id

Q15652

Target Species

Human

Target Name

JMJD1C

Target Full Name

Probable JmjC domain-containing histone demethylation protein 2C

Target Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.

Target Subcellular Location

Nucleus.

Target Protein Families

JHDM2 histone demethylase family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

JHD2C_HUMAN; Jmjd1c; Jumonji domain containing 1C ; Jumonji domain-containing protein 1C; Probable JmjC domain-containing histone demethylation protein 2C; Thryoid receptor interacting protein; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; TRIP8

Target Background

The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants.