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| Cat.No | ACP12534 | Target Name | OPRPN |
|---|---|---|---|
| Target Synonyms | OPRPN; BPLP; PROL1; Opiorphin prepropeptide; Basic proline-rich lacrimal protein; Proline-rich protein 1; PRL1) [Cleaved into: Opiorphin] | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 22-248 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99935 |
|---|
Uniprot Id
Q99935
Target Species
Human
Target Name
OPRPN
Target Full Name
Opiorphin prepropeptide
Target Function
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
Target Subcellular Location
Secreted.
Target Protein Families
PROL1/PROL3 family
Target Tissue Specificity
Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.
Target Synonyms
OPRPN; BPLP; PROL1; Opiorphin prepropeptide; Basic proline-rich lacrimal protein; Proline-rich protein 1; PRL1) [Cleaved into: Opiorphin]
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