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| Cat.No | ACP18597 | Target Name | TGM3 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-467 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q08188 |
|---|
Uniprot Id
Q08188
Target Species
Human
Target Name
TGM3
Target Full Name
Protein-glutamine gamma-glutamyltransferase E
Target Function
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath
Target Involvement
Uncombable hair syndrome 2 (UHS2)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Transglutaminase superfamily, Transglutaminase family
Target Synonyms
E polypeptide protein glutamine gamma glutamyltransferase; MGC126249; MGC126250; Protein glutamine gamma glutamyltransferase E 27 kDa catalytic chain; Protein glutamine gamma glutamyltransferase E 50 kDa noncatalytic chain; Protein glutamine gamma glutamyltransferase E; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; TG(E); TGase E; TGase-3; TGE; TGM 3; TGM3; TGM3_HUMAN; Transglutaminase E; Transglutaminase-3; Transglutaminase3; TransglutaminaseE
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