Recombinant Human Protein lin-9 homolog (LIN9)

Uniprot Id

Q5TKA1

Target Species

Human

Target Name

LIN9

Target Full Name

Protein lin-9 homolog

Target Function

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.

Target Subcellular Location

Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin.

Target Protein Families

Lin-9 family

Target Tissue Specificity

Expressed in thymus and testis.

Target Synonyms

BARA; Beta subunit-associated regulator of apoptosis; Beta-subunit associated regulator of apoptosis; hLin-9; huLin-9; lin-9 ; lin9; LIN9_HUMAN; pRB-associated protein; Protein lin-9 homolog; TGS; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein

Target Background

This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.