Recombinant Human Protein max (MAX)

Uniprot Id

P61244

Target Species

Human

Target Name

MAX

Target Full Name

Protein max

Target Function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.

Target Involvement

Pheochromocytoma (PCC)

Target Subcellular Location

Nucleus. Cell projection, dendrite.

Target Protein Families

MAX family

Target Tissue Specificity

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

MAX; BHLHD4Protein max; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X

Target Background

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.