Recombinant Human Protein-serine O-palmitoleoyltransferase porcupine (PORCN)

Uniprot Id

Q9H237

Target Species

Human

Target Name

PORCN

Target Full Name

Protein-serine O-palmitoleoyltransferase porcupine

Target Function

Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.

Target Involvement

Focal dermal hypoplasia (FODH)

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

Membrane-bound acyltransferase family, Porcupine subfamily

Target Tissue Specificity

Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, s

Target Research Area

Stem Cells

Target Synonyms

DHOF; FODH; MG61; MGC29687; por; PORC; PORCN; PORCN_HUMAN; PPN; Probable protein-cysteine N-palmitoyltransferase porcupine; Protein MG61

Target Background

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.