Recombinant Human Protein unc-13 homolog A (UNC13A), Truncated

Uniprot Id

Q9UPW8

Target Species

Human

Target Name

UNC13A

Target Full Name

Protein unc-13 homolog A

Target Function

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes.

Target Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic active zone.

Target Protein Families

Unc-13 family

Target Tissue Specificity

Expressed in pancreatic islet cells. Expressed in melanocytes.

Target Research Area

Metabolism

Target Synonyms

UNC13A; KIAA1032; Protein unc-13 homolog A; Munc13-1

Target Background

This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.