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| Cat.No | ACP08758 | Target Name | MAS1 |
|---|---|---|---|
| Target Synonyms | MAS1; MAS; Proto-oncogene Mas | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-36 |
| Protein Length | Partial, the first extracellular domain | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P04201 |
|---|
Uniprot Id
P04201
Target Species
Human
Target Name
MAS1
Target Full Name
Proto-oncogene Mas
Target Function
Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
Target Involvement
The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Synonyms
MAS1; MAS; Proto-oncogene Mas
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