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| Cat.No | ACP17650 | Target Name | RSPO4 |
|---|---|---|---|
| Target Synonyms | C20orf182; CRISTIN4; hRspo4; R-spondin family, member 4; R-spondin-4; Roof plate-specific spondin-4; RSPO4; RSPO4_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 20-234 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q2I0M5 |
|---|
Uniprot Id
Q2I0M5
Target Species
Human
Target Name
RSPO4
Target Full Name
R-spondin-4
Target Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
Target Involvement
Nail disorder, non-syndromic congenital, 4 (NDNC4)
Target Subcellular Location
Secreted.
Target Protein Families
R-spondin family
Target Synonyms
C20orf182; CRISTIN4; hRspo4; R-spondin family, member 4; R-spondin-4; Roof plate-specific spondin-4; RSPO4; RSPO4_HUMAN
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