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| Cat.No | ACP18276 | Target Name | IQGAP2 |
|---|---|---|---|
| Target Synonyms | IQ motif containing GTPase activating protein 2; IQGA2_HUMAN; Iqgap2; Ras GTPase activating-like protein; Ras GTPase-activating-like protein IQGAP2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13576 |
|---|
Uniprot Id
Q13576
Target Species
Human
Target Name
IQGAP2
Target Full Name
Ras GTPase-activating-like protein IQGAP2
Target Function
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Target Tissue Specificity
Isoform 2 expression is enhanced in testis.
Target Synonyms
IQ motif containing GTPase activating protein 2; IQGA2_HUMAN; Iqgap2; Ras GTPase activating-like protein; Ras GTPase-activating-like protein IQGAP2
Target Background
This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants.
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