Recombinant Human Ras-related GTP-binding protein C (RRAGC)

Uniprot Id

Q9HB90

Target Species

Human

Target Name

RRAGC

Target Full Name

Ras-related GTP-binding protein C

Target Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Target Involvement

RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.

Target Subcellular Location

Cytoplasm. Nucleus. Lysosome.

Target Protein Families

GTR/RAG GTP-binding protein family

Target Synonyms

AU041672; FLJ13311; GTPase interacting protein 2; GTPase-interacting protein 2; GTR2; MGC47404; OTTHUMP00000000548; Rag C; Rag C protein; RAGC; Ras related GTP binding C; Ras-related GTP-binding protein C; RP23 29H22.4; RRAGC; RRAGC_HUMAN; TIB929; YGR163W

Target Background

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants.