Recombinant Human Ras-related protein Rab-39B (RAB39B)

Uniprot Id

Q96DA2

Target Species

Human

Target Name

RAB39B

Target Full Name

Ras-related protein Rab-39B

Target Function

Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission.

Target Involvement

Mental retardation, X-linked 72 (MRX72); Waisman syndrome (WSMN)

Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus.

Target Protein Families

Small GTPase superfamily, Rab family

Target Tissue Specificity

Highly expressed in the brain.

Target Synonyms

RAB39B; Ras-related protein Rab-39B