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Presenting our premium Recombinant Human REG3A protein, also known as Regenerating islet-derived protein 3-alpha (REG-3-alpha), a crucial component for advancing research in the field of immunology. REG3A is a C-type lectin protein that displays antibacterial activity and plays a vital role in the innate immune response, particularly in the pancreas and gastrointestinal tract. Our Recombinant Human REG3A protein is expressed in E.coli, ensuring the full length of the mature protein (27-175aa) is obtained. The N-terminal GST-tag allows for efficient purification while preserving the protein's native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our REG3A protein guarantees consistent and reliable results in your research applications. Available in both liquid and lyophilized powder forms, our Recombinant Human REG3A protein is ready to support your scientific endeavors.
Presenting our premium Recombinant Human REG3A protein, also known as Regenerating islet-derived protein 3-alpha (REG-3-alpha), a crucial component for advancing research in the field of immunology. REG3A is a C-type lectin protein that displays antibacterial activity and plays a vital role in the innate immune response, particularly in the pancreas and gastrointestinal tract.
Our Recombinant Human REG3A protein is expressed in E.coli, ensuring the full length of the mature protein (27-175aa) is obtained. The N-terminal GST-tag allows for efficient purification while preserving the protein’s native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our REG3A protein guarantees consistent and reliable results in your research applications. Available in both liquid and lyophilized powder forms, our Recombinant Human REG3A protein is ready to support your scientific endeavors.
| Cat.No | ACP04462 | Target Name | REG3A |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 27-175aa | Mol Weight | 43.6kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q06141 |
|---|
Uniprot Id
Q06141
Target Species
Human
Target Name
REG3A
Target Full Name
Regenerating islet-derived protein 3-alpha
Target Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
Target Subcellular Location
Secreted. Note=Found in the apical region of pancreatic acinar cells.
Target Tissue Specificity
Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chroni
Target Research Area
Immunology
Target Synonyms
FLJ18565; Hepatocarcinoma intestine pancreas; Hepatointestinal pancreatic protein; HIP; HIP/PAP; Human proislet peptide; INGAP; Pancreatic beta cell growth factor; Pancreatitis associated protein 1; Pancreatitis associated protein; Pancreatitis-associated protein 1; PAP; PAP H; PAP homologous protein; PAP1; PBCGF; Proliferation inducing protein 34; Proliferation inducing protein 42; Reg III alpha; REG III; Reg III-alpha; REG-3-alpha; REG3; Reg3a; REG3A_HUMAN; Regenerating islet derived 3 alpha; Regenerating islet derived protein 3 alpha precursor; Regenerating islet-derived protein 3-alpha 15 kDa form; Regenerating islet-derived protein III-alpha
Target Background
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.
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