Recombinant Human Retinoic acid receptor responder protein 2 (RARRES2)

The recombinant Human RARRES2 was expressed with the amino acid range of 21-157. The calculated molecular weight for this RARRES2 protein is 31.9 kDa. This protein is generated in a e.coli-based system. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of RARRES2, making it easier to detect and purify the RARRES2 recombinant protein in the later stages of expression and purification.Human retinoic acid receptor responder protein 2 (RARRES2) acts as a chemoattractant, modulating immune responses and adipocyte function. RARRES2 is expressed in adipose tissue and the liver, playing a role in metabolic regulation and insulin sensitivity. Additionally, it participates in inflammation, angiogenesis, and cell differentiation. Its diverse functions implicate RARRES2 in metabolic disorders, cardiovascular diseases, and cancer. As a potential biomarker, it attracts attention in therapeutic research. Understanding the intricate roles of RARRES2 contributes to unraveling its implications in health and disease, spanning immunology, metabolism, and cancer biology.

ACP02528

Number

Cat.No	ACP02528	Target Name	RARRES2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	21-157aa	Mol Weight	31.9kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02528

Target Name

RARRES2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

21-157aa

Mol Weight

31.9kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q99969

Background Information

Uniprot Id

Q99969
Target Species

Human
Target Name

RARRES2
Target Full Name

Retinoic acid receptor responder protein 2
Target Function

Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
Target Subcellular Location

Secreted.
Target Tissue Specificity

Expressed at the highest levels in placenta, liver, and white adipose tissue (WAT), and to a lesser extent in many other tissues such as lung, brown adipose tissue, heart, ovary, kidney, skeletal muscle and pancreas. Within WAT, expression is enriched in
Target Research Area

Neuroscience
Target Synonyms

HP10433; RAR responsive protein TIG2; RAR-responsive protein TIG2; RARR2_HUMAN; RARRES2; Retinoic acid receptor responder (tazarotene induced) 2; Retinoic acid receptor responder 2; Retinoic acid receptor responder protein 2; Tazarotene induced gene 2 protein; Tazarotene-induced gene 2 protein; TIG2
Target Background

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi.

Recombinant Human Retinoic acid receptor responder protein 2 (RARRES2)

Specifications

Immunogen Information

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