Recombinant Human Rho GTPase-activating protein 11B (ARHGAP11B)

Uniprot Id

Q3KRB8

Target Species

Human

Target Name

ARHGAP11B

Target Full Name

Inactive Rho GTPase-activating protein 11B

Target Function

Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.

Target Subcellular Location

Mitochondrion matrix.

Target Synonyms

ARHGAP11B; FAM7B1; Rho GTPase-activating protein 11B; Protein FAM7B1; Rho-type GTPase-activating protein 11B

Target Background

Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix.