Recombinant Human Rho GTPase-activating protein 44 (ARHGAP44), Truncated

Uniprot Id

Q17R89

Target Species

Human

Target Name

ARHGAP44

Target Full Name

Rho GTPase-activating protein 44

Target Function

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation

Target Subcellular Location

Cell projection, dendritic spine. Recycling endosome. Cell junction, synapse, presynapse. Cell projection, dendrite.

Target Tissue Specificity

Highly expressed in brain. Expressed at weak level in other tissues.

Target Synonyms

ARHGAP44; KIAA0672; RICH2; Rho GTPase-activating protein 44; NPC-A-10; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; RICH-2