Recombinant Human Rho-related GTP-binding protein RhoD (RHOD)

Uniprot Id

O00212

Target Species

Human

Target Name

RHOD

Target Full Name

Rho-related GTP-binding protein RhoD

Target Function

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome.

Target Protein Families

Small GTPase superfamily, Rho family

Target Tissue Specificity

Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Target Research Area

Signal Transduction

Target Synonyms

ARHD; Ras homolog D; Ras homolog gene family member A; Ras homolog gene family member D; Rho; RHO D; Rho related GTP binding protein RhoD; Rho related protein HP1; Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RHOD; RHOD_HUMAN; RhoHP1; RHOM

Target Background

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene.