Recombinant Human Rho-related GTP-binding protein RhoG (RHOG)

Uniprot Id

P84095

Target Species

Human

Target Name

RHOG

Target Full Name

Rho-related GTP-binding protein RhoG

Target Function

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side.

Target Protein Families

Small GTPase superfamily, Rho family

Target Research Area

Signal Transduction

Target Synonyms

ARHG; Ras homolog family member G; Rho G; Rho related GTP binding protein RhoG precursor ; Rho-related GTP-binding protein RhoG; RHOG; RHOG_HUMAN

Target Background

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.