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| Cat.No | ACP19198 | Target Name | RNF157 |
|---|---|---|---|
| Target Synonyms | RNF157; KIAA1917; E3 ubiquitin ligase RNF157; EC 2.3.2.27; RING finger protein 157; RING-type E3 ubiquitin transferase RNF157 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-679 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96PX1 |
|---|
Uniprot Id
Q96PX1
Target Species
Human
Target Name
RNF157
Target Full Name
E3 ubiquitin ligase RNF157
Target Function
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle.
Target Subcellular Location
Cytoplasm.
Target Synonyms
RNF157; KIAA1917; E3 ubiquitin ligase RNF157; EC 2.3.2.27; RING finger protein 157; RING-type E3 ubiquitin transferase RNF157
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