Recombinant Human RNA-binding protein with multiple splicing (RBPMS)

Uniprot Id

Q93062

Target Species

Human

Target Name

RBPMS

Target Full Name

RNA-binding protein with multiple splicing

Target Function

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, P-body.

Target Tissue Specificity

Ubiquitously expressed, at various levels depending on the isoform and the tissue.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

FLJ32971; Heart and RRM expressed sequence; Hermes; RBP MS; RBP-MS; Rbpms; RBPMS_HUMAN; RNA binding protein gene with multiple splicing; RNA-binding protein with multiple splicing

Target Background

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.