Recombinant Human RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1), Truncated

Uniprot Id

Q9Y5B0

Target Species

Human

Target Name

CTDP1

Target Full Name

RNA polymerase II subunit A C-terminal domain phosphatase

Target Function

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.

Target Involvement

Congenital cataracts, facial dysmorphism, and neuropathy (CCFDN)

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

CCFDN; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; CTD of POLR2A, phosphatase of, subunit 1; CTDP1; CTDP1_HUMAN; EC 3.1.3.16 ; RNA polymerase II subunit A C terminal domain phosphatase; RNA polymerase II subunit A C-terminal domain phosphatase; Serine phosphatase FCP1a; TFIIF associating CTD phosphatase ; TFIIF-associating CTD phosphatase 1 ; TFIIF-associating CTD phosphatase; Transcription factor IIF-associating CTD phosphatase 1