Recombinant Human Roundabout homolog 2 (ROBO2), Truncated

Uniprot Id

Q9HCK4

Target Species

Human

Target Name

ROBO2

Target Full Name

Roundabout homolog 2

Target Function

Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

Target Involvement

Vesicoureteral reflux 2 (VUR2)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, ROBO family

Target Synonyms

lea; Robo 2; Robo2; ROBO2_HUMAN; Roundabout 2; Roundabout homolog 2; roundabout, axon guidance receptor, homolog 2 (Drosophila); Roundabout2; SAX 3; SAX3

Target Background

The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants.