Recombinant Human Serine/arginine-rich splicing factor 6 (SRSF6)

Uniprot Id

Q13247

Target Species

Human

Target Name

SRSF6

Target Full Name

Serine/arginine-rich splicing factor 6

Target Function

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Target Subcellular Location

Nucleus. Nucleus speckle.

Target Protein Families

Splicing factor SR family

Target Synonyms

arginine/serine-rich 6; B52; Epididymis secretory protein Li 91; fc17h09; HEL S 91; MGC128807 ; MGC5045; Pre mRNA splicing factor SRP55; Pre-mRNA-splicing factor SRP55; Serine/arginine-rich splicing factor 6; SFRS6; Splicing factor; Splicing factor arginine/serine rich 55 kDa; Splicing factor arginine/serine rich 6; SR splicing factor 6; SRP55; SRSF6; SRSF6_HUMAN; wu:faa54g02; wu:fc17h09; zgc:103497

Target Background

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.