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| Cat.No | ACP05911 | Target Name | LMTK3 |
|---|---|---|---|
| Target Synonyms | LMTK3; KIAA1883; TYKLM3; Serine/threonine-protein kinase LMTK3; EC 2.7.11.1; Lemur tyrosine kinase 3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96Q04 |
|---|
Uniprot Id
Q96Q04
Target Species
Human
Target Name
LMTK3
Target Full Name
Serine/threonine-protein kinase LMTK3
Target Function
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons.
Target Subcellular Location
Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections.
Target Protein Families
Protein kinase superfamily, Tyr protein kinase family
Target Synonyms
LMTK3; KIAA1883; TYKLM3; Serine/threonine-protein kinase LMTK3; EC 2.7.11.1; Lemur tyrosine kinase 3
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