Recombinant Human Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)

Uniprot Id

P30153

Target Species

Human

Target Name

PPP2R1A

Target Full Name

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Target Function

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.

Target Involvement

Mental retardation, autosomal dominant 36 (MRD36)

Target Subcellular Location

Cytoplasm. Nucleus. Chromosome, centromere. Lateral cell membrane. Cell projection, dendrite.

Target Protein Families

Phosphatase 2A regulatory subunit A family

Target Synonyms

2AAA_HUMAN; 6330556D22Rik; Alpha isoform of regulatory subunit A; protein phosphatase; DKFZp470L0914; Medium tumor antigen-associated 61 kDa protein; MGC128399; MGC786; MGC83000; MGC95083; PP2A Aalpha; PP2A; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PP2A; subunit A; PR65-alpha isoform; PP2A; subunit A; R1-alpha isoform; PP2AAALPHA; Ppp2r1a; ppp2r1a-b; PR65; PR65-alpha; PR65A; Protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); alpha isoform; Protein phosphatase 2 (Formerly 2A); regulatory subunit A (PR 65); alpha isoform; isoform CRA_a; Protein phosphatase 2 (formerly 2A); regulatory subunit A,; Protein phosphatase 2 regulatory subunit A alpha; Protein phosphatase 2; 65-KD regulatory subunit A; alpha; Protein phosphatase 2; regulatory subunit A; alpha isoform; Protein phosphatase 2; structural/regulatory subunit A; alpha; PPP2R1A; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Target Background

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.