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This Human PPP1CC recombinant protein was produced in E.coli, where the gene sequence encoding Human PPP1CC (2-323aa) was expressed with the N-10xHis tag and C-Myc tag. The purity of this PPP1CC protein was greater than 85% by SDS-PAGE.PPP1CC is a member of the protein phosphatase 1 (PP1) family, which is a serine/threonine protein phosphatase. Its primary function is to remove phosphate groups from proteins, thereby regulating the activity of various cellular signaling pathways. PPP1CC's substrates within the cell include protein kinases, phosphorylated proteins, and more. By dephosphorylating these substrates, it can influence essential biological processes such as cell growth, differentiation, apoptosis, and metabolism.PPP1CC interacts with multiple proteins, including cyclin-dependent kinases, apoptosis-regulating proteins, nuclear factors, and more. These interactions allow it to modulate the activities of these proteins, thereby controlling cellular behaviors.Abnormal expression or mutations in PPP1CC are associated with the development of various diseases. For example, it is linked to the development of certain tumors because it can affect the regulation of the cell cycle. Additionally, abnormal activity of PPP1CC is also associated with some neurological disorders as it can impact the function of neurons.
This Human PPP1CC recombinant protein was produced in E.coli, where the gene sequence encoding Human PPP1CC (2-323aa) was expressed with the N-10xHis tag and C-Myc tag. The purity of this PPP1CC protein was greater than 85% by SDS-PAGE.PPP1CC is a member of the protein phosphatase 1 (PP1) family, which is a serine/threonine protein phosphatase. Its primary function is to remove phosphate groups from proteins, thereby regulating the activity of various cellular signaling pathways. PPP1CC’s substrates within the cell include protein kinases, phosphorylated proteins, and more. By dephosphorylating these substrates, it can influence essential biological processes such as cell growth, differentiation, apoptosis, and metabolism.PPP1CC interacts with multiple proteins, including cyclin-dependent kinases, apoptosis-regulating proteins, nuclear factors, and more. These interactions allow it to modulate the activities of these proteins, thereby controlling cellular behaviors.Abnormal expression or mutations in PPP1CC are associated with the development of various diseases. For example, it is linked to the development of certain tumors because it can affect the regulation of the cell cycle. Additionally, abnormal activity of PPP1CC is also associated with some neurological disorders as it can impact the function of neurons.
| Cat.No | ACP05006 | Target Name | PPP1CC |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-323aa | Mol Weight | 44.3 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P36873 |
|---|
Uniprot Id
P36873
Target Species
Human
Target Name
PPP1CC
Target Full Name
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Target Function
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center.
Target Protein Families
PPP phosphatase family, PP-1 subfamily
Target Research Area
Cancer
Target Synonyms
PP 1G; PP-1G; PP1C; PP1G; PP1G_HUMAN; PP1gamma; PPP 1G; PPP1CC; PPP1G; Protein phosphatase 1; catalytic subunit; gamma isozyme; Protein phosphatase 1C catalytic subunit; Serine/threonine phosphatase 1 gamma; Serine/threonine protein phosphatase PP1 gamma catalytic subunit; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Target Background
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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