Recombinant Human SH3 domain-binding protein 2 (SH3BP2)

Uniprot Id

P78314

Target Species

Human

Target Name

SH3BP2

Target Full Name

SH3 domain-binding protein 2

Target Function

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.

Target Involvement

Cherubism (CRBM)

Target Tissue Specificity

Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.

Target Synonyms

3BP-2; 3BP2; 3BP2_HUMAN; Abl SH3 binding protein 2 ; Cherubism ; CRBM; CRPM; FLJ42079; FLJ54978; RES4-23; SH3 domain binding protein 2; SH3 domain-binding protein 2; Sh3bp2; TNFAIP3 interacting protein 2

Target Background

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.