Recombinant Human Sn1-specific diacylglycerol lipase alpha (DAGLA), Truncated

Uniprot Id

Q9Y4D2

Target Species

Human

Target Name

DAGLA

Target Full Name

Diacylglycerol lipase-alpha

Target Function

Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation

Target Involvement

Spinocerebellar ataxia 20 (SCA20)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Tissue Specificity

Highly expressed in brain and pancreas.

Target Synonyms

C11orf11; Chromosome 11 open reading frame 11 ; DAGL(ALPHA); Dagla; DAGLALPHA; DGL alpha; DGL-alpha; DGLA_HUMAN; Diacylglycerol lipase alpha; KIAA0659; Neural stem cell derived dendrite regulator; Neural stem cell-derived dendrite regulator; NSDDR; Sn1-specific diacylglycerol lipase alpha